Category Archives: Vaccines

Bullet Biotech – Viral-Like Particles Expressing B-cell Idiotypes for Cancer

This example of personalized medicine involves exploiting the highly selective proteins that are expressed by patients’ B-cells. Bullet Biotechnology isolates the specific idiotypic (Id) protein from patients with B-cell lymphomas (CLL – chronic lymphocytic leukemia, and NHL – non-Hodgkin’s lymphoma) and expresses it on the surface of a virus-like particle to provoke a highly specific anti-Id response against B-cell clones expressing the specific Id protein. Continue reading

IND for Clinical Studies of dCellVax Breast Cancer Immune Therapy Filed – Intelligent and Rational Gene Silencing Approach for Cancer

Regen Biopharma recently filed an IND (Investigational New Drug Application) with the FDA to permit the initiation of Phase 1 clinical trials of its dCellVax treatment for advanced breast cancer. Continue reading

Novel mutated antigens from Tumor Infiltrating Lymphocytes from long-term melanoma responders

Tumor Infiltrating Lymphocytes (TILs) are cytotoxic T-cells that are found in tumors.  They serve to destroy cancer, or at least keep cancer at bay.  Adoptive immunotherapy, Continue reading

Genetic Analyses of Cancer – Precision Medicine a New Standard

Memorial Sloan Kettering has started testing the cancers of its patients for 341 cancer-related genes.  It is collaborating with Quest Diagnostics to perform the analyses in an effort to identify biomarkers that can best guide appropriate therapy.  This is precision medicine, and it is happening at other major cancer centers, as well… Continue reading