Celgene acquired EngMab for $600MM to enrich its programs targeting B-cell maturation antigen (BCMA) for the treatment of multiple myeloma. Celgene is exploiting BCMA in both CAR T (chimeric antigen receptor T-cell) and bispecific antibodies targeting CD-3 (Cluster of differentiation 3), Continue reading
Tag Archives: Amgen
Vectibix Extends Survival in Colon Cancer
A Phase III study in patients with chemo-refractory colorectal cancer with wild-type K-ras genotype demonstrated that Amgen’s Vectibix (panitumumab) improved overall survival compared to best supportive therapy, alone. A total of 377 patients were randomized to receive best supportive care with or without intravenous infusions of Vectibix every 14 days. Full results of the study will be presented at a future medical meeting and submitted for publication. Continue reading
T-VEC Receives Advisory Committee Recommendation for Melanoma
On April 29, the FDA Oncology Drug Advisory Committee voted 22-1 to recommend approval of Amgen’s talimogene laherparepvec (T-VEC) for the treatment of patients with advanced melanoma. Continue reading
Kyprolis FOCUS Phase 3 Study for Multiple Myeloma
Last week, Amgen (Onyx) announced negative news from its FOCUS clinical trial of multiple myeloma drug Kyprolis. Let’s put this into perspective. Continue reading