Tag Archives: NHL

CAR T-cell more effective than standard of care in refractory Non-Hodgkin Lymphoma

The FDA granted approval of axicabtagene ciloleucel (YESCARTA) on October 25, 2017, two months following the approval of tisagenlecleucel (KYMRIAH) – both are anti-CD19-directed CAR T (chimeric antigen receptor T-cell) therapies that employ re-programmed autologous T-cells to fight cancer: Continue reading

Juno Advances CAR T-cell CAR017 and Halts CAR015 in Non-Hodgkin Lymphoma

Juno Therapeutics is developing Chimeric Antigen Receptor (CAR) T-cells directed against B-cell antigen CD19 for the treatment of patients with B-cell lymphomas. The company has elected to halt the development of JCAR015 for Acute Lymphoblastic Leukemia (ALL) and proceed with JCAR017 for relapsed/refractory diffuse large B-cell lymphoma (DLBCL), the most common form of Non-Hodgkin Lymphoma (NHL), due to the development of cerebral edema and subsequent death of several patients with ALL enrolled in its phase 2 ROCKET trial, which has been suspended. Continue reading

Bullet Biotech – Viral-Like Particles Expressing B-cell Idiotypes for Cancer

This example of personalized medicine involves exploiting the highly selective proteins that are expressed by patients’ B-cells. Bullet Biotechnology isolates the specific idiotypic (Id) protein from patients with B-cell lymphomas (CLL – chronic lymphocytic leukemia, and NHL – non-Hodgkin’s lymphoma) and expresses it on the surface of a virus-like particle to provoke a highly specific anti-Id response against B-cell clones expressing the specific Id protein. Continue reading