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The Texas 2 Step Approach to Cancer Cyberwarfare via Exosomes

Multi-modality (surgery, chemo, radiation) therapy and combination chemotherapy (e.g, CHOP and ABVD) have long been the mainstays of treating cancer. So, we should not be surprised to read about the discovery made by scientists at Rice University and MD Anderson regarding a two-step approach involving radiation and immunotherapy. Continue reading

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Chop Protein Suppresses the Immune Response in Cancer

The Chop protein, not to be confused with the CHOP chemotherapy regimen for lymphoma (Cyclophosphamide, Hydro doxorubicin – Adriamycin, Oncovin – vincristine, and Prednisone), is a multifunctional transcription factor. This 29 kda protein that is produced following unfolded protein stress in the endoplasmic reticulum, which then triggers apoptosis. Continue reading

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Selectively Targeting Metabolism in Mitochondria In Cancer Cells

An experimental drug, CPI-613, was shown to be safe and induce several responses in a Phase I study of patients with advanced refractory hematologic malignancies. The drug targets mitochondrial enzymes of cancer cells and is not harmful to normal cells at therapeutic doses. Continue reading

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Attacking Brain Cancer in its Hypoxic Environment

As tumors grow and become unresponsive to external cellular signals, the level of oxygen in the masses decreases; mutated cells, those with malfunctioning p53, grow and thrive greater than 0.2 mm from the blood supply. Continue reading

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Obesity soon to replace tobacco as the number one preventable / treatable cause of cancer

“Obesity is on its way to replacing tobacco as the number one preventable / modifiable cause of cancer,” says Clifford Hudis, MD, the 2013-2014 President of the American Society of Clinical Oncology. Indeed, obese post-menopausal women have up to twice the risk of developing breast cancer as do their normal weight counterparts. Continue reading

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Why more males develop brain tumors than females

It is widely known that brain tumors, in particular glioblastomas and medulloblastomas, affect males more than females. Moreover, given the age of onset and analysis of incidence by age, sex hormones have been ruled-out as the cause. Continue reading

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Kyprolis FOCUS Phase 3 Study for Multiple Myeloma

Last week, Amgen (Onyx) announced negative news from its FOCUS clinical trial of multiple myeloma drug Kyprolis. Let’s put this into perspective. Continue reading

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JAK-inhibitors for myelofibrosis

Last week, pacritinib, an oral tyrosine kinase inhibitor drug-candidate with dual activity against JAK2 and FLT, has been granted Fast Track designation by the U.S. Food & Drug Administration Continue reading

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IDO inhibition in cancer immunology

IDO ( indoleamine 2,3-dioxygenase) is a molecule that oxidizes tryptophan, which is needed by cytotoxic T-cells. When cancer cells and T-reg cells secrete IDO in the vicinity of cytotoxic T cells, antitumor activity is abrogated.   Continue reading

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Targeted therapies for cancer – overview

The National Cancer Institute has a very informative, yet easy to understand overview  presented as a Q&A – Targeted Cancer Therapies. Continue reading