cancerBiology180x110

Rexahn – 3 Novel Cancer Products in Development

I attended the Rexahn presentation at the Biotech Showcase on January 12-14, 2015. The company has 3 novel anti-cancer products in the clinic. Continue reading

cancerBiology180x110

Adenosine Receptor Agonist for Liver Cancer

Can-Fite BioPharma announced that it has dosed the first patient in a Phase II trial for the treatment of hepatocellular carcinoma (HCC), the most common form of liver cancer. The study will enroll 78 patients with refractory advanced hepatocellular carcinoma  with Child-Pugh Class B cirrhosis. Patients will receive 25 mg of CF102 orally twice a day; the endpoint will be overall survival between those receiving CF102 versus placebo. Continue reading

cancerBiology180x110

Mystery of Myeloid-Derived Suppressor Cells in Cancer SOLVED

Researchers at St. Jude Children’s hospital have identified the population of white blood cells that tumors use to propagate their growth AND to suppress the immune system.   Continue reading

3LINVBW

Merck Acquires OncoEthix for Novel MYC Blocker

Last week, Merck acquired OncoEthix at a price of $375 MM for OTX015, a synthetic small molecule which targets the BET bromodomain proteins 2, 3, and 4 (BRD2/3/4). Continue reading

cancerBiology180x110

Activin (TGF-β) Receptor ActRIIA Antagonists for Myelodysplastic Syndrome & β-Thalassemia

Two experimental drugs, luspatercept and sotatercept, have shown to be active in myelodysplastic syndrome (MDS), a type of cancer in which the bone marrow does not make enough healthy blood cells and there are abnormal (blast) cells in the blood and/or bone marrow. Continue reading

cancerBiology180x110

New Epidermal Growth Factor Strategies in the Clinic for Glioblastoma & Lung Cancer

Two companies, Celldex and Clovis, reported positive developments with their strategies to target the mutated Epidermal Growth Factor Receptor for patients with glioblastoma and lung cancer. Continue reading

cancerBiology180x110

Tissue Phenomics for Biomarker Identification in Active Immuno-Oncology Therapy

To date, the search for biomarkers to best guide active immunologic therapy selection and monitoring of response has not been fruitful. Unlike molecular targeted therapies and monoclonal antibodies for which the presence of mutated or over-expressed proteins (e.g., Philadelphia Chromosome, B-raf, HER-2, and CD20) is a prerequisite to use, Continue reading

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Amgen’s Trebananib Does Not Meet Overall Survival Endpoint in Phase Study of Ovarian Cancer Patients

Angiopoietin inhibitor, trebananib, did not extend overall survival (OS) in a Phase 3 study in ovarian cancer. In the TRINOVA-1 trial of 900 women with recurrent ovarian cancer following platinum-based chemotherapy, patients receiving trebananib plus paclitaxel had a 19.3 month overall survival versus 18.3 months OS for women receiving paclitaxel, alone.  The difference was not statistically significant. Continue reading