cancerBiology180x110

Two New Drugs Effective in Kidney Cancer – Opdivo and Cometriq

Opdivo (nivolumab – BMS) and Cometriq (cabozantinib -Exelixis) demonstrated positive results in studies of patients with kidney cancer. Renal cell carcinoma is the most common type of kidney cancer in adults, accounting for more than 100,000 deaths annually. Globally, the five-year survival rate for those diagnosed with metastatic, or advanced kidney cancer, is 12.1 percent. Continue reading

cancerBiology180x110

Immunocor’s Anti-Cancer Platform Garners $320MM Private Financing

Immunocor raised $320MM in a private financing round to support its anti-cancer platform. That’s a lot of money for a single financing – in fact, it is the largest private fundraising by a European biotechnology company. What’s the attraction? Continue reading

cancerBiology180x110

EGFR Antibody Necitumumab Recommended for Lung Cancer & Other Anti-EGFR MAb’s to Address EGFR Resistance

The Oncology Drug Advisory Committee voted (informally) to recommend approval of Lilly’s necitumumab in combination with gemcitabine and cisplatin for the first-line treatment of patients with locally advanced or metastatic squamous non–small cell lung cancer (NSCLC). Continue reading

cancerBiology180x110

Lung Cancer Drug for Patients with Resistant T790 EGFR Mutation

The epidermal growth factor receptor (EGFR) receives signals from outside the cell that promote cell division and block apoptosis, leading to proliferation, invasion, and metastasis. Continue reading

cancerBiology180x110

Circulating Exosomes for Early Diagnosis of Pancreatic Cancer

The best way to cure cancer is to catch it early when surgical removal of a localized mass can successfully rid the patient of all cancer cells and cancer stem cells. This is no more important than in pancreatic cancer for which late stage therapies have not been shown to be very effective. (Thank you, Elaine, for sending me this article to discuss on the blog.) Continue reading

cancerBiology180x110

Vectibix Extends Survival in Colon Cancer

A Phase III study in patients with chemo-refractory colorectal cancer with wild-type K-ras genotype demonstrated that Amgen’s Vectibix (panitumumab) improved overall survival compared to best supportive therapy, alone. A total of 377 patients were randomized to receive best supportive care with or without intravenous infusions of Vectibix every 14 days. Full results of the study will be presented at a future medical meeting and submitted for publication. Continue reading

Lycera’s ROR-gamma agonists for cancer immunotherapy

Celgene and Lycera entered into a $105MM collaboration on its RORϒ agonists for the treatment of cancer, as well as LYC-30937, an oral gut-directed ATPase modulator now in early-stage clinical studies. LYC-30937 is designed to treat IBD without global immune suppression. Continue reading

cancerBiology180x110

What do pineapples, glucose, and cancer have in common – mitochondria

I was sent articles by two non-cancer researchers last week – they are quite fitting for discuss on this blog (thank you, Gina and Sherilyn). The first was on DCA (dichloroacetate), a drug approved for congenital lactic acidosis, and the second about bromelain, an enzyme in pineapples. Continue reading

cancerBiology180x110

Ibrance plus Faslodex Improves Outcomes in HR+ Breast Cancer

In a Phase 3 Paloma-III study of Pfizer’s CDK4/6 inhibitor (Ibrance – palbociclib) and an estrogen receptor antagonist (Faslodex – fulvestrant), patients receiving the combination had significantly prolonged progression-free survival than women with breast cancer who received Faslodex, alone. Continue reading

cancerBiology180x110

Prostate Cancer Genetic Map Unveiled

Researchers have identified a handful of mutations in patients with advanced prostate cancer for which therapeutics are already available, or in development. The genomes of 150 patients with metastatic (Stage 4) hormone-resistant disease were analyzed in order to develop a precision medicine framework for the treatment of advanced prostate cancer. Continue reading