Last week, Merck acquired OncoEthix at a price of $375 MM for OTX015, a synthetic small molecule which targets the BET bromodomain proteins 2, 3, and 4 (BRD2/3/4). Continue reading
Category Archives: Oncogenes
Cell Medica’s Antigen-Specific T-cells for Lymphoma
Cell Medica, a London-based biotech company, raised $78MM in a Series B financing with several accomplished biotech investors on the strength of data from its clinical trials in patients with EBV (Epstein Barr Virus) associated lymphomas. Continue reading
Reprogramming Lung Cancer to Self-Destruct Using TRAIL and CDK9 Inhibitor
CANCER RESEARCH UK scientists have found a drug combination that can trigger the self-destruct process in lung cancer cells – paving the way for new treatments, according to research that will be presented at the National Cancer Research Institute (NCRI) Cancer Conference in Liverpool next week. This process is known as apoptosis. Continue reading
Super Enhancer Switches for Gene Regulation – Syros
Biotech company Syros Pharmaceuticals just raised $53.1 MM in a Series B financing after raising a $30 MM Series A financing in 2013. This is big money for a small company – and, the money comes from some very savvy biotech investment funds. Continue reading
Targeted therapies for cancer – overview
The National Cancer Institute has a very informative, yet easy to understand overview presented as a Q&A – Targeted Cancer Therapies. Continue reading
Monoclonal antibodies + kinase inhibitors are better than antibodies alone in breast cancer and B-cell lymphoma
The combination of Herceptin plus pan-HER (EGFR and Her 2 an 4) kinase inhibitor neratinib resulted in a 33% improvement in progression free survival versus Herceptin alone in breast cancer patients. Rituxan combined with idelalisib, PI3K inhibitor, resulted in a near doubling of progression-free survival at 24 weeks versus Rituxan, alone in patients with Chronic Lymphocytic Leukemia, non-Hodgkin’s Lymphoma, and small cell lymphoma. The news for neratinib tripled the valuation of Puma Biotechnology, while the FDA granted approval of Gilead’s drug Zydelig (idelalisib). Continue reading
Cancer diagnostics in clinical use
Diagnostics that not only diagnose cancer, but also help select the appropriate therapy and monitor response are a mainstay in modern oncology, and their use is growing. Precision medicine, identifying genetic markers of disease and designing treatments to exploit these, is the essence of targeted cancer therapy. Continue reading
Ras – targeting the “undruggable”
The Ras onogene has been studied for 30 years, with over 40,000 scientific articles published on it. However, an inhibitor of the mutated form of Ras has not been able to be developed. So, researchers have developed downstream blockers of the Ras cascade – MEK inhibitors and Raf inhibitors, for example. But why can’t a molecule that blocks mutated Ras be identified? Continue reading
HPV DNA Test and Experimental DNA Vaccine
The National Cancer Institute states that “virtually all” cervical cancers are caused by HPV infection. The association is so strong that the FDA recently approved a DNA test for HPV that many believe could supplant PAP smear. This is great news for patients who do not have cervical cancer, yet. But what if you do?… Continue reading
Precision Medicine: SWOG Lung-MAP study – unique public/private collaboration
Using genomics to take-on advanced non-small cell lung cancer, the Southwest Oncology Group announced the start of a master protocol that will screen patients for optimal eligibility into one of five clinical trials with experimental drugs… Continue reading