Cancer Biology

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Cancer Biology

Tag Archives: CSF-1

Argos’ Metastatic Renal Cell Carcinoma Study Passes Independent Data Safety Monitoring Committee Second Interim Analysis

An independent data monitoring committee (IDMC) has recommended the continuation of Argos’ pivotal phase 3 ADAPT clinical trial of AGS-003 for the treatment of metastatic renal cell carcinoma (mRCC) based on results of the committee’s second planned interim data analysis. The next planned interim analysis will be in 6 months. Continue reading →

This entry was posted in active immunotherapy, Receptor Tyrosine Kinase Inhibitors, Uncategorized, Vaccines and tagged Argos, CD4+, CD40 ligand, CD40L, CD8+, CSF-1, dendritic cells, immune tolerance, KIT, metastatic renal cell carcinoma, MHC Class I, MHC Class II, mRCC, PDGF, RET, sunitinib, Sutent, VEGF on January 13, 2016 by Joseph Gulfo.

CSF-1 Inhibitor PLX3397 + Keytruda (Anti-PD1) for Multiple Cancers

Colony Stimulating Factor (CSF-1) is an essential growth factor for cells of the monocyte-macrophage lineage, including osteoclasts.
Continue reading →

This entry was posted in Checkpoint Inhibitors, Heterotypic Cellular Interactions, Oncogenes, Uncategorized and tagged CSF-1, Keytruda, MDSC, Myeloid-Derived Suppressor Cells, PLX3397 on May 13, 2015 by Joseph Gulfo.


This blog is designed to provide updates in developments in cancer biology and engage in discussions about new findings in the field.

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