Tag Archives: macrophage

Enhanced ADCC technologies to improve cancer cytotoxicity

Antibody Dependent Cell-Mediated Cytotoxicity (ADCC) is a process by which the Fab (variable region) of antibodies, produced by B-cells, first bind to antigens on target cells (cancer), and their Fc (constant regions) then bind white cells (macrophages, granulocytes, and NK – natural killer cells), which destroy the target cells. ┬áThe antibodies opsonize the target and then attract white cells to destroy the target. Continue reading