Tag Archives: VEGF

MET – an ideal target for antibody drug conjugate therapy, plus nivolumab

MET is a gene that encodes a receptor tyrosine kinase that is activated upon binding with hepatocyte growth factor (HGF, or Scatter Factor). Specifically, MET is a Continue reading

Combined CA4P (Fosbretabulin) therapy in Cancer- Ashini R. Dias, Contributor

Malignant tumors cannot grow beyond a certain size without establishing blood supply to feed them with necessary nutrients and oxygen. The process of recruiting new blood vessels to the tumor is termed angiogenesis. Growth factors, mainly secreted by the tumor itself, induce angiogenesis; the most notable of these is vascular endothelial growth factor (VEGF), which helps endothelial precursor cells mature into neo-capillary forming, endothelial cells. These secrete other growth factors, like platelet derivative growth factor (PDGF), which attracts pericytes and vascular smooth muscle cells that, together, create the outer layers of capillaries.   Continue reading

Pancreatic cancer drug that mimics heparin halted in Phase 2 for lack of efficacy

A Phase 2 study of necuparanib (from Momenta Pharmaceuticals) was halted following an interim futility analysis. The data and safety monitoring board (DSMB) ran the analysis once 57 patients in the 120-person trial had died, leading to the conclusion that necuparanib was showing insufficient efficacy to justify continuing the study. Continue reading

Combined Endoglin and VEGF Monoclonal Antibody Therapy in Cancer – Subasinghe Nissanga A Dias, Contributor

Blood vessel formation (angiogenesis) is an important pathologic process in solid tumors. The liberation of vast amounts of vasoendothelial growth factor (VEGF), which attracts endothelial cells, is responsible for angiogenesis. Continue reading

Argos’ Metastatic Renal Cell Carcinoma Study Passes Independent Data Safety Monitoring Committee Second Interim Analysis

An independent data monitoring committee (IDMC) has recommended the continuation of Argos’ pivotal phase 3 ADAPT clinical trial of AGS-003 for the treatment of metastatic renal cell carcinoma (mRCC) based on results of the committee’s second planned interim data analysis. The next planned interim analysis will be in 6 months. Continue reading

Amgen’s Trebananib Does Not Meet Overall Survival Endpoint in Phase Study of Ovarian Cancer Patients

Angiopoietin inhibitor, trebananib, did not extend overall survival (OS) in a Phase 3 study in ovarian cancer. In the TRINOVA-1 trial of 900 women with recurrent ovarian cancer following platinum-based chemotherapy, patients receiving trebananib plus paclitaxel had a 19.3 month overall survival versus 18.3 months OS for women receiving paclitaxel, alone.  The difference was not statistically significant. Continue reading

Genspera G-202 – anti-cancer hand grenade

Genspera is a company developing novel prodrugs for the treatment of cancer.  In a phase 2 study in patients with hepatocellular carcinoma who have failed treatment with Nexavar (sorafenib), a tyrosine kinase inhibitor that blocks KIT, FLT-3 RET, raf, VEGFR1-3, and PDGF kinases, a doubling of time to progression was seen in patients taking G-202. Continue reading

Lilly’s Ramucirumab (anti-VEGF-2 receptor MAb) does not meet overall survival endpoint in Phase III liver cancer study

Ramucirumab, a monoclonal antibody that targets the VEGF2 (Vascular Endothelial Factor – 2) receptor failed to meet its Overall Survival endpoint in Phase III clinical study in patients with liver cancer… Continue reading