Tag Archives: glucose-6-phosphate

WP1122 is a 2-deoxy-D-glucose prodrug in pre-clinical development for glioblastoma

The Warburg Effect is a universal feature of cancer; it describes the phenomenon whereby cancer cells preferentially use glucose for anaerobic glycolysis, as opposed to aerobic respiration via the Krebs Cycle. In order to meet the increased energy demands using a much less efficient process for ATP production, cancer cells take-up 20-times more glucose than wild-type cells. Continue reading