Tag Archives: CD28/B7 superfamily

arGENX – Immune Checkpoint Control of TNFR Superfamliy

A Dutch biotechnology company called arGENX raised $54 MM in an IPO (initial public offering) yesterday to advance its antibody pipeline.  Its lead product, ARGX-110 is in late Phase 1 studies for hematologic malignancies.  It is an immune checkpoint control modulator that acts on the CD70/CD27 axis, which is part of the TNFR superfamily, not the CD28/B7 superfamliy of co-stimulatory molecules. Continue reading