Researchers at the University of North Carolina have been developing a chemotherapy drug treatment utilizing iontophoresis specifically for prostate and breast cancer. Continue reading
Category Archives: Signal Transduction
Rexahn – 3 Novel Cancer Products in Development
I attended the Rexahn presentation at the Biotech Showcase on January 12-14, 2015. The company has 3 novel anti-cancer products in the clinic. Continue reading
Kevetrin – p53 Inducer by Cellceutix
Thioureidobutyronitrile (Kevetrin) is an intravenous drug currently in a Phase 1 study in patients with advanced solid malignancies. It acts by promoting apoptosis in several ways: Continue reading
Adenosine Receptor Agonist for Liver Cancer
Can-Fite BioPharma announced that it has dosed the first patient in a Phase II trial for the treatment of hepatocellular carcinoma (HCC), the most common form of liver cancer. The study will enroll 78 patients with refractory advanced hepatocellular carcinoma with Child-Pugh Class B cirrhosis. Patients will receive 25 mg of CF102 orally twice a day; the endpoint will be overall survival between those receiving CF102 versus placebo. Continue reading
Merck Acquires OncoEthix for Novel MYC Blocker
Last week, Merck acquired OncoEthix at a price of $375 MM for OTX015, a synthetic small molecule which targets the BET bromodomain proteins 2, 3, and 4 (BRD2/3/4). Continue reading
Activin (TGF-β) Receptor ActRIIA Antagonists for Myelodysplastic Syndrome & β-Thalassemia
Two experimental drugs, luspatercept and sotatercept, have shown to be active in myelodysplastic syndrome (MDS), a type of cancer in which the bone marrow does not make enough healthy blood cells and there are abnormal (blast) cells in the blood and/or bone marrow. Continue reading
New Epidermal Growth Factor Strategies in the Clinic for Glioblastoma & Lung Cancer
Two companies, Celldex and Clovis, reported positive developments with their strategies to target the mutated Epidermal Growth Factor Receptor for patients with glioblastoma and lung cancer. Continue reading
Obesity soon to replace tobacco as the number one preventable / treatable cause of cancer
“Obesity is on its way to replacing tobacco as the number one preventable / modifiable cause of cancer,” says Clifford Hudis, MD, the 2013-2014 President of the American Society of Clinical Oncology. Indeed, obese post-menopausal women have up to twice the risk of developing breast cancer as do their normal weight counterparts. Continue reading
Why more males develop brain tumors than females
It is widely known that brain tumors, in particular glioblastomas and medulloblastomas, affect males more than females. Moreover, given the age of onset and analysis of incidence by age, sex hormones have been ruled-out as the cause. Continue reading
Kyprolis FOCUS Phase 3 Study for Multiple Myeloma
Last week, Amgen (Onyx) announced negative news from its FOCUS clinical trial of multiple myeloma drug Kyprolis. Let’s put this into perspective. Continue reading