Elegant Themes has just released a plugin that gives you all the functionality of the page builder built into the Divi theme, allowing you to use its advanced page-builder features in most any theme you choose. As in the full theme package, the Builder comes with a set of ready-made layout options, and many content modules that you place with a drag-and-drop interface.
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WPMUDEV is going into “builder” themes in a big way. These are themes that have drag-and-drop interfaces that let you create pages in layouts that go beyond the usual header/body/sidebar/footer model that you’re used to. Each page can have its own individual collection of modules and blocks than contain images, menus, slideshows, videos, in whatever arrangement you like. The (current) home page of TLTC Blogs is built using one of these types of themes, “Divi” from Elegant Themes.
Everyone’s going mobile — are you ready?
Both of these are very specialized tools, with more than a few quirks. Especially in Annotum, the learning curve is fairly steep and prone to trial-and-error. But they impose sensible workflow solutions and organize information in a way that a standard theme or plug-in does not.