Tag Archives: histone acetylation

BET Bromodomain Inhibition in Prostate Cancer Treatment

BET bromodomain inhibitors are epigenetic regulators that act by repressing expression of oncogenes, including MYC and BCL-2, that are aberrantly highly expressed in many cancer cells, resulting in inhibited cell proliferation and induction of apoptotic cell death. Continue reading

Epigenetic-modulation in myelodysplastic syndrome – DNA methylation and histone acetylation

Epigenetic regulation is critical for gene expression.  Epigenetic pathways are frequently dysregulated in cancer, which can lead to suppression of tumor suppressor genes and expression of oncogenes. Continue reading