Tag Archives: HDAC inhibitor

Beleodaq, a new pan-HDAC inhibitor approved for peripheral T-cell lymphoma

HDAC inhibitors work by blocking Histone De-ACetylase enzyme, which removes acetyl groups from the proteins that encase DNA, that is histones.  They are triggered by CpG sequences on DNA promoters; HDACs put chromatin in a configuration that favors LACK of transcription.  So, blocking HDACs favors transcription – see prior postContinue reading