Tag Archives: indoleamine 2 3-dioxygenase

IDO inhibition in cancer immunology

IDO ( indoleamine 2,3-dioxygenase) is a molecule that oxidizes tryptophan, which is needed by cytotoxic T-cells. When cancer cells and T-reg cells secrete IDO in the vicinity of cytotoxic T cells, antitumor activity is abrogated.   Continue reading