As the field of global health grows, the network of stakeholders and the influences on program development become more complex. Future leaders need to be prepared with skills to navigate and negotiate within the increasing global health governance structures. Leaders in education have called for new techniques to engage students through active and experiential learning. Simulation education, which has been used in fields such as political science and policy making, is perfectly suited to meet educators’ needs in teaching global health governance, program development and response. This article describes the creation of a global health related simulation and a discussion of the framework from which it was developed and implemented. This could be used as a template to develop other global health related simulations.