This Funding Opportunity Announcement (FOA) is issued by the National Institute of Neurological Disorders and Stroke (NINDS) in conjunction with the NIH Pain Consortium. It solicits R01 grant applications from institutions/organizations to perform innovative research that will elucidate the mechanisms underlying migraine, expand our current knowledge of the role of genetic, physiological, biopsychosocial, and environmental influences in migraine susceptibility and progression, and explore new therapeutic targets and therapies for acute migraine management and longer term prevention.

This FOA is intended to attract innovative and cross-disciplinary applications to expand our current knowledge and management of migraine. Research of interest includes the study of predictive and susceptibility factors, the mechanisms underlying the phases of migraine, modulatory influences that induce and sustain headache, and both pharmacological and non-pharmacological therapy development. The research community is encouraged to expand on the emerging scientific discoveries related to neural and inflammatory mechanisms, maladaptive plastic changes in the nervous system associated with chronic headache, and genetic contributions to migraine. This Announcement also highlights the need to explore endogenous, genetic, environmental, and lifestyle triggers and influences on migraine.

Open date for earliest submission:  May 5, 2014

For more information, please refer to: http://grants.nih.gov/grants/guide/pa-files/PA-14-068.html