Functional Assays to Screen Genomic Hits

This funding opportunity announcement by the National Heart, Lung & Blood Institute aims to use in vitro or animal model systems to better understand genetic variations in heart, lung, blood and sleep phenotypes. Research should include, but is not limited to:

  • Known genetic variations in coding sequences
  • Genetic variants in putative regulatory regions
  • Multi-variant analysis

Proposals should not:

  • Solely measure gene expression to assess gene functions
  • Propose only in silico or cell-free testing of variants
  • Fail to propose functional assays to test the impact of genetic variants
  • Focus on finding new genetic variants through new GWAS studies, additional genotyping or new or additional sequencing to confirm genetic findings or identify new genes of interest

Project periods cannot exceed five years and awards will vary with the scope of the project. Submissions open on December 23, 2012. For more information, see the link below:

http://grants.nih.gov/grants/guide/rfa-files/RFA-HL-13-027.html#_Part_1._Overview

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