Although Malaysia is not a treaty ally of the United States, the two countries have had longstanding and institutionalized relations. However, the two countries’ alignment on issues pertaining to defense and security has been increasingly colored by ambiguity and ambivalence. While the Biden Administration raises hopes that the Malaysia-US Comprehensive Partnership will be strengthened, it is likely that old and new ambiguities will endure in sectoral, strategic, and other spheres. This webinar will trace the changing structural and domestic conditions underpinning these ambiguities, before presenting a preliminary assessment on the prospects and problems of the Malaysia-United States alignment in the post-pandemic era.