{"id":720,"date":"2014-09-03T11:15:51","date_gmt":"2014-09-03T15:15:51","guid":{"rendered":"http:\/\/blogs.shu.edu\/cancer\/?p=720"},"modified":"2021-07-02T08:51:58","modified_gmt":"2021-07-02T12:51:58","slug":"obesity-soon-to-replace-tobacco-as-the-number-one-preventable-treatable-cause-of-cancer","status":"publish","type":"post","link":"http:\/\/blogs.shu.edu\/cancer\/2014\/09\/03\/obesity-soon-to-replace-tobacco-as-the-number-one-preventable-treatable-cause-of-cancer\/","title":{"rendered":"Obesity soon to replace tobacco as the number one preventable \/ treatable cause of cancer"},"content":{"rendered":"

\u201cObesity is on its way to replacing tobacco as the number one preventable \/ modifiable cause of cancer,\u201d says Clifford Hudis, MD, the 2013-2014 President of the American Society of Clinical Oncology. Indeed, obese post-menopausal women have up to twice the risk of developing breast cancer as do their normal weight counterparts.<\/p>\n

First, the biology behind the link to between obesity and cancer:<\/p>\n

    \n
  1. Obese patients have increased levels of insulin and IGF-1<\/a> (insulin-like growth factor 1), therefore, greater stimulation IGF-1R (insulin-like growth factor receptors), which drive cell growth and cell division;<\/li>\n
  2. Adipocytes have direct and indirect effects on cellular signaling molecules<\/a> (stimulation of mTOR \u2013 mammalian target of rapamycin, which is one of the terminal Akt\/PKB pathway effectors resulting in myc induction, and inhibition of AMP-activated protein kinase which blocks mTOR induction of myc);<\/li>\n
  3. Obesity induces a chronic subacute level of inflammation, which promotes the development of cancer.<\/li>\n<\/ol>\n

    \"igf-1r-mechanism\"<\/a><\/p>\n

    \"nrc2676-f3\"<\/a><\/p>\n

    Second, what is the definition of obesity? The BMI (body mass index) chart from Baylor (http:\/\/www.baylorhearthospital.com\/Knowing-Your-Numbers.html<\/a>) shows the BMI given your height and weight. If you are 5\u20196\u201d and weigh 230 pounds, or 6\u20192\u201d and weigh 270 pounds, you are severely obese.<\/p>\n

    \"bmi_chart\"<\/a><\/p>\n

    Third, some more startling facts:<\/p>\n

      \n
    1. In colorectal cancer, obesity at the time of diagnosis is linked to a higher risk of recurrence and death;<\/li>\n
    2. Obese and overweight women have 2-4 times the risk of developing endometrial cancer, and 90% of women with the most common type of endometrial cancer (Type 1) are obese;<\/li>\n
    3. \u00a0Individuals with a BMI of 30 or more, have 2 times the risk of developing pancreatic cancer;<\/li>\n
    4. 30% of new cases of kidney cancer are attributable to obesity;<\/li>\n
    5. BMI is positively correlated with prostate cancer progression to lethal disease, while inversely associated with incidence.<\/li>\n<\/ol>\n

      And finally, the obesity epidemic is only getting worse, especially in children where the rate of childhood obesity in 6 to 11 year olds increased from 5% in 1980 to 18% in 2010, and for 12 to 18 year olds it increased from 7% in 1980 to 18% in 2010.<\/p>\n

      Obesity of preventable and treatable. We must do a better job.<\/p>\n

      Here\u2019s the link\u2026tell me what you think<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

      \u201cObesity is on its way to replacing tobacco as the number one preventable \/ modifiable cause of cancer,\u201d says Clifford Hudis, MD, the 2013-2014 President of the American Society of Clinical Oncology. Indeed, obese post-menopausal women have up to twice the risk of developing breast cancer as do their normal weight counterparts.<\/p>\n","protected":false},"author":2252,"featured_media":394,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[12,11,18,9,10,4,1],"tags":[406,169,408,405,404,403,407,189],"class_list":["post-720","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cell-cycle","category-diet-nutrition","category-heterotypic-cellular-interactions","category-mortality","category-prevention","category-signal-transduction","category-uncategorized","tag-amp-kinase","tag-breast-cancer","tag-endometrial-cancer","tag-igf-1","tag-mtor","tag-obesity-2","tag-pancreatic-cancer","tag-prostate-cancer"],"post_mailing_queue_ids":[],"_links":{"self":[{"href":"http:\/\/blogs.shu.edu\/cancer\/wp-json\/wp\/v2\/posts\/720","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/blogs.shu.edu\/cancer\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/blogs.shu.edu\/cancer\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/blogs.shu.edu\/cancer\/wp-json\/wp\/v2\/users\/2252"}],"replies":[{"embeddable":true,"href":"http:\/\/blogs.shu.edu\/cancer\/wp-json\/wp\/v2\/comments?post=720"}],"version-history":[{"count":4,"href":"http:\/\/blogs.shu.edu\/cancer\/wp-json\/wp\/v2\/posts\/720\/revisions"}],"predecessor-version":[{"id":4998,"href":"http:\/\/blogs.shu.edu\/cancer\/wp-json\/wp\/v2\/posts\/720\/revisions\/4998"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/blogs.shu.edu\/cancer\/wp-json\/wp\/v2\/media\/394"}],"wp:attachment":[{"href":"http:\/\/blogs.shu.edu\/cancer\/wp-json\/wp\/v2\/media?parent=720"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/blogs.shu.edu\/cancer\/wp-json\/wp\/v2\/categories?post=720"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/blogs.shu.edu\/cancer\/wp-json\/wp\/v2\/tags?post=720"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}